Double Stranded DNA Fragmentation Test
Comet Extend Test
Double Stranded DNA Fragmentation Test
The Double-Stranded DNA Fragmentation Test (Comet Extend) is an advanced sperm test designed to detect severe DNA damage that may not be identified through standard fertility testing.
We are currently the only fertility clinic in the UK offering this test for direct online booking, available in London (TDL) and Beaconsfield.
FERTILITY SOLUTIONS
Why does sperm DNA matter?
Sperm DNA carries the genetic blueprint required for embryo development. Even when standard semen parameters are normal, underlying DNA damage can affect fertilisation, embryo development, implantation, and miscarriage risk.
Understanding DNA Damage
DNA can be visualised as a ladder. Single-strand breaks affect one side and may be repairable.
Double-strand breaks affect both sides and are significantly harder to repair, often leading to poorer outcomes.
What makes the Comet Extend test different?
This test specifically measures double-strand DNA breaks, providing a more precise and clinically meaningful assessment compared to standard fragmentation tests.
FERTILITY SOLUTIONS
Who should consider this test?
Anyone who has:
- Unexplained infertility
- Recurrent miscarriage
- Failed IVF with no clear cause
- Poor embryo development or implantation failure
- Normal PGT-A embryos with failed outcomes
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What's next?
What Changes If This Test Is Abnormal?
Results may guide clinical decisions such as sperm selection methods, lifestyle interventions, and
treatment strategy adjustments.
Test Preparation
No strict abstinence required. Recommended: 2–5 days.
Locations
London (TDL) and Beaconsfield
Follow-Up
A consultation is strongly recommended to interpret results and plan next steps.
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Contact Us
We understand that embarking on any treatment journey is daunting and fertility treatment is no different. The team at Fertility Solutions is here to guide you every step of the way. Our aim is to take the mystery away, help you make sense of the medical information and provide, simple, clear facts about what is possible for you.